Whole genome sequencing of murine T-ALL

In this study we analyzed the genomes of murine T cell acute lymphocytic leukemias (T-ALL) developing upon thymus autonomy. The project contains whole genome sequencing data from 30 T-ALLs, 13 autonomous thymi and ten germline controls obtained from C57BL/6 mice. In addition, it contains peripheral blood samples from 2 mice at, respectively, 3 and 4 time points and single cell clonal expansions of 6 single T cells from 2 normal mice. All samples were sequenced on Illumina HiSeqX PE150. The target coverage was 90x for 6 T-ALLs, for all autonomous thymi and for 2 germline controls. The remaining samples were sequenced at 30x target coverage.