Grignard Addition to Imines Derived from Isatine: A Method for the Asymmetric Synthesis of Quaternary 3-Aminooxindoles
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https://figshare.com/articles/dataset/Grignard_Addition_to_Imines_Derived_from_Isatine_A_Method_for_the_Asymmetric_Synthesis_of_Quaternary_3_Aminooxindoles/2848846
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资源简介：
Addition of Grignard reagents to chiral imines derived from isatine afforded chiral, optically enriched 3-substituted 3-aminooxindoles in satisfactory yields and diastereoisomeric ratios. A general protocol is described for the addition of alkyl, alkenyl, and aryl Grignard reagents. In one case, the absolute configuration at C3 was determined and the selective N-deprotection was described, enabling further synthetic transformations of the reaction product.
创建时间：
2016-02-26
