Ligand Promoted Olefination of Anilides for Indirectly Introducing Fluorinated Functional Groups via Palladium Catalyst
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https://figshare.com/articles/dataset/Ligand_Promoted_Olefination_of_Anilides_for_Indirectly_Introducing_Fluorinated_Functional_Groups_via_Palladium_Catalyst/13650700
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资源简介：
We report a palladium-catalyzed,
ligand promoted, C–H fluorine-containing
olefination of anilides with 4-bromo-3,3,4,4-tetrafluorobutene as
the fluorinated reagent, which has a potential transformation into
other compounds due to its -CF2CF2Br functional group. -CF2CF2H
was obtained by using the mild reducing agent sodium borohydride.
Bioactive compounds such as aminoglutethimide derivative and propham
were well-tolerated in this reaction, both of which highlight the
synthetic importance of this method.
创建时间：
2021-01-27
