Crystal structure of MERS 3CL protease in complex with a dimethyl sulfinyl benzene inhibitor
收藏Protein Data Bank Japan2024-10-23 更新2026-04-25 收录
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Crystal structure of MERS 3CL protease in complex with a dimethyl sulfinyl benzene inhibitor Descriptor: (2~{S})-2-[[(2~{S})-4-methyl-2-[[2-methyl-2-[oxidanyl(phenyl)-$l^{3}-sulfanyl]propoxy]carbonylamino]pentanoyl]amino]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propane-1-sulfonic acid, N~2~-(ethoxycarbonyl)-N-{(1S,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-1-sulfanylpropan-2-yl}-L-leucinamide, Orf1a protein Authors: Liu, L, Lovell, S, Battaile, K.P, Dampalla, C.S, Groutas, W.C. Deposit date: 2022-08-22 Release date: 2022-09-07 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV). Eur.J.Med.Chem., 254, 2023
创建时间：
2022-08-22
