Sebaceous Neoplasm Tissue Study, 20190101. Sebaceous Neoplasm Tissue Study, 20190101

Sebaceous carcinoma, a rare but aggressive skin cancer, often shares clinicopathologic features with benign sebaceous neoplasms, complicating accurate diagnosis. This study aimed to identify molecular biomarkers to improve classification and treatment strategies by analyzing the genomic and transcriptomic profiles of sebaceous neoplasms from multiple U.S. healthcare facilities. Investigators from six U.S. institutions, including Emory University, Stanford University, and others, contributed de-identified, formalin-fixed paraffin-embedded (FFPE) samples and clinical data for sebaceous neoplasms diagnosed between 1999 and 2021. The study focused on tumors from patients who tested negative for Lynch syndrome-related mismatch repair gene mutations or had no germline testing, aiming to... (for more see dbGaP study page.)