Transcriptome analysis of TFAM-depleted HepG2 cells and HeLa cells. Transcriptome analysis of TFAM-depleted HepG2 cells and HeLa cells

We conducted transcriptome analysis of TFAM-depleted HepG2 cells and HeLa cells as a mitochondrial stress model. We found that mitochondrial dysfunction upregulated unique secretory proteins such as amphiregulin (AREG) and thrombospondin 1 in hepatic cells. Overall design: We depleted TFAM in HepG2 human hepatic cells or HeLa human cervix adenocarcinoma cells using two different siRNAs, and then carried out an expression microarray experiment.