STUDY OF COAGULATION PROFILE IN TYPE 2 DIABETES MELLITUS

Introduction:Diabetes mellitus is a chronic condition which has high risk for microvascular and macrovascular comorbidities by the process ofbinding of glucose molecules tovariousproteinsinvolvedinthecoagulationmechanism. The current study was carried out to determine the coagulation profiles of type 2 diabetes mellitus patients in comparison with apparently healthy controls.

Methods:This was a comparative cross-sectional study carried out atTertiary careteaching institute Ahmedabad. Platelet parameters were determined by using HoribaPentraXLRautomated Hematology analyzer, whereas coagulation analysis was done using ACLTOP300CTSFullyAutomatedCoagulometer. The descriptive and analytical analysis was performed using MicrosoftExcel and SPSS software. We used student t-testtoanalyzethedifferencebetweenthemeans.AP-valuelessthan0.05wasset forthestatisticalsignificancedetermination.

Result: The mean PT, INR and APTT in the Diabeticcase group were 11.46±1.63,0.98±1.14and29.83±4.09respectively.Thereweresignificantdifferences (p value<0.05) in the PT, INR and APTT between caseandhealthycontrolgroups.The mean platelet count was 257.92±75.48 and the mean MPV was8.00±1.03.

Conclusion: The present study revealed reduced values ofPT,INR,APTT and no significant differences in platelet countsand MPVbetweendiabeticpatients andhealthycontrols.Thus,thefindingissuggestive of hyper- coagulable tendencies of diabetic patients compared to controls.