PROMIS Pediatric Asthma Study

This study aimed to compare the responsiveness to change of the Patient-Reported Outcomes Measurement Information System (PROMIS®) asthma impact and generic scales to a legacy scale, the Paediatric Asthma Quality of Life Questionnaire (PAQLQ). 229 child-parent dyads in public insurance programs were enrolled. PROMIS Pediatric Short Forms and the PAQLQ were used to measure health-related quality of life (HRQoL) across 4 time points (T1 to T4) over 2 years; the Asthma Control and Communication Instrument was used to measure change of asthma control; Global Rating of Change (GRC) for breathing problems and overall health were used to measure change of health status. Responsiveness was tested by comparing the changes of HRQoL with change of asthma control and health status over time using t-tests, generalized estimating equation, and relative validity approaches. The PROMIS asthma impact scale (p<0.05) and all PAQLQ scales (p’s<0.05) exhibited significant responsiveness when anchored to asthma control and health status. Several PROMIS generic scales (pain, fatigue, and mobility) also indicated adequate responsiveness. The PROMIS asthma impact scale indicated similar responsiveness to the PAQLQ. Due to its brevity and responsiveness, the PROMIS asthma impact scale is useful for clinical practice or research.