PROMIS Pediatric Asthma Study

This study aimed to compare the responsiveness to change of the Patient-Reported Outcomes Measurement Information System (PROMIS®) asthma impact and generic scales to a legacy scale, the Paediatric Asthma Quality of Life Questionnaire (PAQLQ). 229 child-parent dyads in public insurance programs were enrolled. PROMIS Pediatric Short Forms and the PAQLQ were used to measure health-related quality of life (HRQoL) across 4 time points (T1 to T4) over 2 years; the Asthma Control and Communication Instrument was used to measure change of asthma control; Global Rating of Change (GRC) for breathing problems and overall health were used to measure change of health status. Responsiveness was tested by comparing the changes of HRQoL with change of asthma control and health status over time using t-tests, generalized estimating equation, and relative validity approaches. The PROMIS asthma impact scale (p<0.05) and all PAQLQ scales (p’s<0.05) exhibited significant responsiveness when anchored to asthma control and health status. Several PROMIS generic scales (pain, fatigue, and mobility) also indicated adequate responsiveness. The PROMIS asthma impact scale indicated similar responsiveness to the PAQLQ. Due to its brevity and responsiveness, the PROMIS asthma impact scale is useful for clinical practice or research.

本研究旨在对比患者报告结局测量信息系统（Patient-Reported Outcomes Measurement Information System, PROMIS®）哮喘影响量表与通用量表，相较于传统量表《儿童哮喘生活质量调查问卷》（Paediatric Asthma Quality of Life Questionnaire, PAQLQ）的变化响应性。本研究共纳入229组参与公共保险项目的亲子对，在2年随访期内的4个时间点（T1至T4），采用PROMIS儿科简表与PAQLQ评估受试者的健康相关生活质量（health-related quality of life, HRQoL）；采用哮喘控制与沟通工具评估哮喘控制情况的变化；采用呼吸问题与整体健康整体变化评级量表（Global Rating of Change, GRC）评估健康状态的变化。本研究通过t检验、广义估计方程（generalized estimating equation）与相对效度分析法，对比不同时间点下健康相关生活质量的变化与哮喘控制、健康状态的变化，以检验各量表的响应性。结果显示，PROMIS哮喘影响量表（p<0.05）与所有PAQLQ分量表（所有p值<0.05）在锚定哮喘控制与健康状态时，均表现出显著的响应性；部分PROMIS通用量表（疼痛、疲劳与活动能力维度）同样展现出良好的响应性。PROMIS哮喘影响量表的响应性与PAQLQ相当。鉴于其简洁性与良好的响应性，PROMIS哮喘影响量表可有效应用于临床实践与相关研究工作中。