Collagen peptide promotes DSS-Induced colitis by disturbing gut microbiota

Collagen peptide (CP) has anti-inflammatory and antioxidant activities. However, the effect and mechanism of CP on UC are not clear. In this study, we aimed to explore the role of CP in UC. The results showed that CP diet promoted the progression of DSS-induced colitis, increased the expression of inflammatory factors and the infiltration of macrophages in the lamina propria of colon. Gut microbiota analysis showed the composition changed significantly and inflammation promoted bacteria was further increased after CP treatment.