Performance of the tool AMYLPRED2 and of its subordinate methods, on a set of 33 amyloidogenic proteins (see Table S1).

True/false positives (TP, FP) and true/false negatives (TN, FN) for each method were counted on a per residue basis. Sensitivity is measured as TP/(TP + FN), specificity as TN/(TN + FP), Q is calculated as (Sensitivity + Specificity)/2 and Matthews Correlation Coefficient (MCC) as (TP * TN – FP * FN)/√((TN + FN) * (TN + FP) * (TP + FN) * (TP + FP)).