The activity of trans-membrane proteins such as ion channels is the essence of neuronal transmission. The currently most accurate method for determining ion channel kinetic mechanisms is single-channe
The modeled C. elegans ion channels (second column), grouped on the basis of ion selectivity (first column) are classified according to vertebrate homologues (third column) and corresponding nematode
Ion channel models present many challenging optimisation problems. These include unidentifiable parameters, noisy data, unobserved states, and a combination of both fast and slow timescales. This can
