Crystal structure of human Cdk13/Cyclin K in complex with the inhibitor THZ531
收藏Protein Data Bank Japan2024-11-13 更新2026-04-19 收录
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Crystal structure of human Cdk13/Cyclin K in complex with the inhibitor THZ531 Descriptor: Cyclin-K, Cyclin-dependent kinase 13, N-[4-[(3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide Authors: Anand, K, Greifenberg, A.K, Kaltheuner, I.H, Geyer, M. Deposit date: 2021-03-18 Release date: 2021-05-12 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. Eur.J.Med.Chem., 221, 2021
创建时间：
2021-03-18
