Time-resolved serial oscillation crystallography applied to light-driven DNA repair

Name: Time-resolved serial oscillation crystallography applied to light-driven DNA repair
Creator: University of Hamburg,Pearson Group,Luruper Chaussee 149,HARBOR, Building 610,22761 HAMBURG,22761,HAMBURG,GERMANY; National Taiwan University,Department of Chemistry,No.1 Sec.4 Roosevelt Road,10617 TAIPEI,TAIWAN,10617 ,TAIPEI,TAIWAN; National Taiwan University; Academia Sinica,Institute of Biological Chemistry,128 Sec. 2, Academia Road,Nankang,115 TAIPEI,115,TAIPEI,TAIWAN
Published: 2027-01-01 00:00:00
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ESRF Portal2027-01-01 更新2026-04-23 收录

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https://doi.esrf.fr/10.15151/ESRF-ES-1873390281

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Members of the photolyase-cryptochrome superfamily (PCSF) utilise transient electron transfer (ET) for diverse reactions including light-driven DNA repair, and photo- and magnetoreception. As such, they represent a ubiquitous and central class of enzymes which has attracted an enormous amount of attention. Over the last years⁠, our group has specialised in the time-resolved crystallographic characterisation of these reactions, with one exception: repair of (6-4) Photoproduct (64PP) DNA lesions via (6-4)Photolyases. With the current proposal, we aim to employ Time-resolved serial oscillation crystallography (TR-SOX) techniques to structurally characterise this reaction for the first time.

提供机构：

University of Hamburg,Pearson Group,Luruper Chaussee 149,HARBOR, Building 610,22761 HAMBURG,22761,HAMBURG,GERMANY; National Taiwan University,Department of Chemistry,No.1 Sec.4 Roosevelt Road,10617 TAIPEI,TAIWAN,10617 ,TAIPEI,TAIWAN; National Taiwan University; Academia Sinica,Institute of Biological Chemistry,128 Sec. 2, Academia Road,Nankang,115 TAIPEI,115,TAIPEI,TAIWAN

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2027-01-01

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