Data from: Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p

Circular RNAs (circRNAs) participate in the occurrence and progression of
many cancers. CircRNA ataxin 7 (circATXN7) (circBase ID: hsa_circ_0066436)
plays a promoting influence on gastric cancer progression. However, the
biological role of circATXN7 in non-small cell lung cancer (NSCLC) is
indistinct. CircATXN7 and PFN2 were highly expressed in NSCLC, whereas
miR-7-5p expression had the opposite trend. CircATXN7 overexpression
constrained apoptosis and promoted proliferation, metastasis, invasion,
and epithelial-mesenchymal transition (EMT) of NSCLC cells, but circATXN7
silencing played the opposing influence and repressed xenograft tumor
growth in vivo. CircATXN7 served as a miR-7-5p sponge, and circATXN7
regulated malignant behaviors of NSCLC cells through sponging miR-7-5p.
PFN2 acted as a miR-7-5p target. PFN2 silencing overturned the promoting
effect of miR-7-5p inhibitor on NSCLC cell malignancy, while PFN2
overexpression reversed the inhibitory impact of miR-7-5p mimic on NSCLC
cell malignancy. CircATXN7 accelerated the malignancy of NSCLC cells
through adsorbing miR-7-5p and upregulating PFN2, offering evidence to
support circATXN7 as a might target for NSCLC treatment.