Measured binding kinetics data for wt and D374Y mutant PCSK9- LDL-R [12].
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Fold differences between kon and koff for D374Y versus wt are shown in parenthesis, noting that the t1/2 of the bound complex is similar to that of wt PCSK9, but considerably longer than that of the D374Y mutant (which is likely subject to koff hijacking). The ratio of was calculated based on = 1x108 M-1 s-1, corresponding to ki = 1x10-2 s-1 (predicted from Eq 13 under the assumption that ki = k−i).
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2018-11-01
