Gene expression profile in external auditory canal squamous cell carcinoma

External auditory canal squamous cell carcinoma (EACC) is very rare, only accounting for two thousandth of the head and neck cancer. However, the development mechanism of EACC remains unknown. By using gene expression microarray analysis, we aimed to find differentially expressed genes involved in ESCC development. We identified a wide spectrum of molecular signatures in EACC, including mRNA and lncRNA. The present study systematically analyzed the expression of mRNA and lncRNA in squamous cell carcinoma of the external auditory canal and normal external auditory canal tissues. We detect the transcriptomic changes between squamous cell carcinoma of the external auditory canal and normal external auditory canal tissues to identify potential tumor biomarkers in squamous cell carcinoma of the external auditory canal. We selected patients with external auditory canal squamous cell carcinoma (EACC) who received surgery. The fresh EACC and normal external auditory canal tissues were collected from patients during surgery. Total RNA was extracted. The transcriptomic expression of genes was analyzed on Affymetrix microarrays.