Type I error rates for MBI vary as a function of sample size, statistical comparison, variance, maximum risk of harm, and thresholds for harm/benefit.

Row 1 represents the typical MBI study; subsequent rows demonstrate how changing specific parameters alters the rates; parameters that remain unchanged from the base case are grayed out whereas altered parameters are bolded. Rates were calculated mathematically and also confirmed by simulation with 200,000 repeats (See S1 Appendix for description and S2 Appendix for code).