Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase
收藏Protein Data Bank Japan2024-10-23 更新2026-04-25 收录
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Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase Descriptor: 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, GLYCEROL, Tyrosine-protein kinase BTK, ... Authors: Lin, D.Y, Andreotti, A.H. Deposit date: 2023-03-27 Release date: 2023-08-16 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
创建时间：
2023-03-27
