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Tissue-biased expansion of DNMT3A-mutant clones in a mosaic individual is associated with conserved epigenetic erosion

NIAID Data Ecosystem2026-03-11 收录

体细胞突变克隆扩增

表观遗传修饰

数据链接：

https://data.mendeley.com/datasets/rp3y5snpkk 数据链接链接失效反馈

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资源简介：

Supplemental tables supporting the main figures

应用场景：

创建时间：

2020-07-17

表观遗传修饰

RB1基因

Comparative analysis of H3K9me3 and H3K27me3 in RB1 KO and wild type IMR-90 cells Overall design: Examination of 2 histone modifications in RB1 KO and wild type IMR-90 cells

NIAID Data Ecosystem70

Histone H3 epigenetic modifications ChIPseq

表观遗传修饰

免疫细胞状态分析

ChIPseq analysis of histone H3 epigenetic modification - K27ac - chromatin binding in activated CD4+ T cells Overall design: 3 women, CD4 cells from PBMC isolated by positive selection on Dynabeads (c

NIAID Data Ecosystem40

RNA binds to a CBP regulatory motif to stimulate histone acetylation and transcription

转录调控机制

表观遗传修饰

CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-regulatory elements that control patterns of gene expression in multicellular organisms. Active enhancers produc

NIAID Data Ecosystem40

UTX and 53BP1 co-regulate genetic programs for neural differentiation of human embryonic stem cells [ChIP-seq]. UTX and 53BP1 co-regulate genetic programs for neural differentiation of human embryonic stem cells [ChIP-seq]

神经分化基因调控

表观遗传修饰

UTX is a histone H3 lysine 27 demethylase required for development. However, the mechanisms underlying developmental gene regulation by UTX are unclear. Here, we discovered a molecular interaction bet

NIAID Data Ecosystem60

SIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2

细胞氧化还原调控

表观遗传修饰

We investigated the effect of SIRT6-knockout on gene expression and H3K4me3 modification profile in human mesenchymal stem cells. Overall design: RNAs isolated from SIRT6+/+ and SIRT6-/- hMSCs at earl

NIAID Data Ecosystem40

Tissue-biased expansion of DNMT3A-mutant clones in a mosaic individual is associated with conserved epigenetic erosion

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