CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling

CD109 is a glycosylphosphatidylinositol-anchored glycoprotein highly expressed in several types of human malignant tumors including lung cancers. We investigated the in vivo functions of CD109 protein in malignant lung tumors. CD109+/+ and CD109-/- K-ras[LSL-G12D/+];p53[fl/fl] (KP) mice were sacrificed at 20 to 23 weeks of age and total RNA was extracted from the lung tumors. SurePrint G3 Mouse GE Microarray 8×60K Ver.2.0 were performed. We performed microarray analysis of the lung tumors of CD109+/+ and CD109-/- KP mice in order to investigate which gene sets and pathways are significantly associated with CD109 deficiency.