CALERIE Genomic Data Resource - Summary Data and Code

Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, non-obese humans (NCT00427193) broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n=218 participants during the trial. These data constitute the first genomic data resource for a randomized controlled trial of an intervention targeting the biology of aging. Datasets include whole-genome SNP genotypes, and three-timepoint-longitudinal DNA methylation, mRNA, and small RNA datasets generated from blood, skeletal muscle, and adipose tissue samples (total sample n=2327). The CALERIE Genomic Data Resource described in this article is available from the Aging Research Biobank. This multi-tissue, multi-omic, longitudinal data resource has great potential to advance translational geroscience.

热量限制（Caloric restriction, CR）可延缓模式生物的生物学衰老并延长其健康寿命。针对健康非肥胖人群开展的长期热量限制随机对照试验CALERIE（NCT00427193）的研究结果，大体证实了该干预手段在人类身上也能产生类似的效应模式。为深化我们对人类热量限制效应背后分子通路与生物学过程的认知，本研究从该试验中218名受试者留存的生物样本中生成了一系列基因组数据集。这些数据构成了首个针对衰老生物学干预的随机对照试验基因组数据资源。数据集包含全基因组单核苷酸多态性（Single Nucleotide Polymorphism, SNP）基因型，以及从血液、骨骼肌和脂肪组织样本中生成的三个时间点纵向DNA甲基化（DNA methylation）、信使RNA（messenger RNA, mRNA）与小RNA（small RNA）数据集（总样本量n=2327）。本文所描述的CALERIE基因组数据资源可从衰老研究生物样本库（Aging Research Biobank）获取。这一多组织、多组学、纵向数据资源有望极大推动转化性老年科学的发展。