Spatial Distribution and Correlation Analysis of PD-L1, FOXP3, and CD8 Expression in the Tumor Microenvironment of Penile Squamous Cell Carcinoma: A Tissue Microarray Study

This dataset contains comprehensive immune profiling data from a tissue microarray (TMA) analysis of penile squamous cell carcinoma (PSCC) specimens. The data includes detailed immunological and histopathological parameters, focusing on the tumor microenvironment and immune cell distributions.Dataset StructureThe dataset is organized in a grid format (x, y coordinates) with multiple measurements for each specimen. Each row represents a unique TMA spot with the following variables:Variables DescriptionLocation Variablesx, y: Grid coordinates in TMAsp: Specimen identifiertma: TMA identifier (852)Tumor Characteristicssubtype: Histological subtype (Usual, Warty, Basaloid, Warty-Basaloid)grade: Histological grade (Grade 1-3)ki67_tumor: Proliferation index (%)PD-L1 Expressionpdl1_tumor: Percentage of positive tumor cells (0-100%)pdl1_tumor_location: Subcellular localizationpdl1_tumor_h: H-score (0-300)pdl1_lymph: Percentage of positive lymphocytes (0-100%)Immune Cell Parametersfoxp3_lymph_tumor: FOXP3+ lymphocytes in tumorfoxp3_lymph_stroma: FOXP3+ lymphocytes in stromafoxp3_lymph_intensity: Staining intensity (No staining, Weak, Moderate, Strong)foxp3_tumor: FOXP3+ tumor cellsfoxp3_tumor_intensity: Tumor staining intensitycd8_tumor: CD8+ T cells in tumorcd8_stroma: CD8+ T cells in stromacd8ki67_tumor: CD8+/Ki67+ cells in tumorcd8ki67_stroma: CD8+/Ki67+ cells in stromaHost Responsehost_response: Categories of inflammatory responseNo inflammatory cellsRare inflammatory cellsLymphoid aggregatesIntense inflammationComparative Measurescd8foxp3_tumor: CD8/FOXP3 ratio in tumorcd8foxp3_stroma: CD8/FOXP3 ratio in stromaUsage NotesAll cell counts are reported per high-power fieldPercentages range from 0-100H-scores range from 0-300Related Publicationshttps://www.medrxiv.org/content/10.1101/2024.12.11.24318871v1https://www.medrxiv.org/content/10.1101/2024.12.11.24318853v1