Cranial manipulation modulates cholinergic pathway gene expression in an animal model of age-related cognitive decline
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
In this study, we examine the effect of cranial osteopathic manipulation (COM) on gene expression, in an animal model for age-related cognitive decline (aged rats). We found that COM significantly affected the expression of 36 genes in the neuronal pathway (False Discovery Rate (FDR) < 0.004). The top five neuronal genes with the largest fold-change (Slc5a7, Chat, Slc18a3, Adcy5 and Cacna2d2, >2-fold change, FDR<0.004) are part of the cholinergic neurotransmission mechanism, which is known to affect cognitive function.
提供机构：
Edward Via College of Osteopathic Medici
创建时间：
2022-02-20
