Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE223600
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To investigate the effects of T. cruzi on human cardiomyocytes during infection, we infected induced pluripotent stem cell_x0002_derived cardiomyocytes (iPSC-CM) with the parasite and analyzed responses at 24 hours and 48 hours post infection (hpi) em compared to basal (0hpi - Control) using transcriptomics (RNAseq) We also validated our finds using RNA-seq data from HIF-1alpha mutated iPSC-CM treated with LPS. Comparative gene expression profiling analysis of RNA-seq data for iPSC-CM at day 30 after T. cruzi infection
创建时间:
2023-03-09



