The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution. The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

The bone marrow microenvironment of leukemia plays a key role in leukemia progression, but its molecular complexity in pre-B acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. Here we use single-cell RNA sequencing to characterise the bone marrow microenvironment during B-ALL progression. Overall design: Five samples were collected during B-ALL disease progression at days 0, 3, 6, 9 and 12