Metabolic Transformation of Fat in Obesity Determines the Inflammation Resolving Capacity of Splenocardiac and Cardiorenal Networks in Heart Failure

Chronic and
surplus dietary intake of safflower oil (SO) increased plasma creatinine
dysregulated post-MI splenocardiac inflammation coincides with the dysfunctional cardiorenal network. In contrast,
docosahexaenoic acid (DHA) increases post-MI survival in chronic heart failure.
DHA transforms to specialized proresolving
mediators (SPMs) and limited proinflammatory
prostaglandins and thromboxanes following myocardial infarction (MI). DHA
promotes Ly6Clow resolving macrophages and T regulatory cells (Foxp3+)
in a splenocardiac manner post-MI.