Characterization of POR haplotype distribution in African populations and comparison with other global populations: Supplementary tables

Background & aim: POR is an enzyme that mediates electron transfer to enable the drug-metabolizing
activity of CYP450 proteins. However, POR has been understudied in pharmacogenomics despite this vital
role. The authors aimed to characterize the genetic variation in POR across African populations and
to compare the star allele (haplotype) distribution with that in other global populations. Materials &
methods: POR star alleles were called from whole-genome sequencing data using the StellarPGx pipeline.
Results: In addition to the common POR*1 and *28 haplotypes (defined by rs1057868), five novel rare
haplotypes were computationally inferred. No significant frequency differences were observed among
the majority of African populations. However, POR*28 was observed at a higher frequency in individuals
of non-African ancestry. Conclusion: This study highlights the distribution of POR alleles in Africa and
across global populations with a view toward informing future precision medicine implementation.