Targeted NKX2.1 DamID sequencing data from human fetal lung organoids recapitulating differential developmental features of human lung development

Human fetal lung tip cells were purifed from developing human lungs at pseudoglandular and canalicular stages and in vitro cultured; pseudoglandular organoids and LinPOS organoids, respectively. Alveolar organoids were differentiated from LinPOS organoids in the alveolar differentiation condition. Differential NKX2.1 binding patterns in each organoid were profiled by targeted DamID-seq. Overall design: 1) CD44+ tip population from pseudoglandular organoids, 2) CD36+CD44+ population from LinPOS organoids, 3) Alveolar organoids (three biological replicates for each cell type)