Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons

The goals of this study are to generate and study serotonergic neurons from MDD patients that are selective serotonin reuptake inhibitor (SSRI) remitters and SSRI-nonremitters (NR). Overall design: From patients (NR, R) and healthy controls (H), serotonergic neurons were derived from iPSCs for further study