PROCR diminishes the efficacy of radiation by impairing T cell-mediated antitumour immunity

We found that PROCR promotes IL-6 secretion, which is magnified after radiation, leading to inhibition of antitumour immunity. Next, we investigated the mechanism by which PROCR upregulated IL-6. To this end, we performed RNA sequencing on irradiated HONE1 cells with or without PROCR knockout. High-throughput RNA sequencing analysis was performed in irradiated sgGFP (WT) or sgPROCR (KO) human nasopharyngeal carcinoma cell line HONE1