snRNA-seq dataset for "Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward"

This dataset contains single-nucleus RNA-seq results from rat adult nucleus accumbens tissue treated with CRISPRi machinery (hSyn-driven dCas9-KRAB-MeCP2 fusion) with a CRISPR sgRNA targeting lacZ (a bacterial gene not found in the mammalian genome; used as a non-targeting control) or Reln.本数据集包含采用由突触素启动子（hSyn）驱动的dCas9-KRAB-MeCP2融合蛋白构建的CRISPR干扰（CRISPRi）系统处理的大鼠成年伏隔核组织的单细胞核RNA测序（single-nucleus RNA-seq）结果，该系统所搭载的CRISPR单引导RNA（sgRNA）分别靶向细菌基因lacZ（该基因不存在于哺乳动物基因组中，用作非靶向对照）或Reln基因。