Human RAD54 inhibitor screen: summary of 158 compounds identified as 'hits'
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https://datadryad.org/dataset/doi:10.7272/Q68G8HW8
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资源简介:
This dataset, Human RAD54 inhibitor screen: summary of 158 compounds
identified as 'hits', accompanies the manuscript, Small
molecule inhibitors of a human recombination-associated ATPase,
RAD54. 158 compounds identified as inhibitory to the ATPase
activity of purified human RAD54 on dsDNA (pUC19) in a primary
malachite green phosphate detection assay are catalogued in an Excel
document, with annotation describing follow-up in secondary assays
(including IC50 values, DNA dependence of ATPase inhibition &
class assignments, TopoI inhibition, structural similarity to known DNA
intercalators, SF50 (toxicity to HEK293), combination index (CI) with
mitomycin C (MMC) or cisplatin (CsPt),
reversibility/irreversibility of RAD54 inhibition, PAINS
classifications).
提供机构:
Dryad
创建时间:
2018-11-28



