Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells
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https://figshare.com/articles/dataset/Five_Membered_Ring_Peroxide_Selectively_Initiates_Ferroptosis_in_Cancer_Cells/3080737
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资源简介：
A 1,2-dioxolane (FINO2) was identified as a lead compound
from a screen of organic peroxides. FINO2 does not induce
apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative
cell death pathway. Few compounds are known to induce primarily ferroptosis.
In contrast to the perceived instability of peroxides, FINO2 was found to be thermally stable to at least 150 °C. FINO2 was more potent in cancer cells than nonmalignant cells of
the same type. One of the enantiomers was found to be more responsible
for the observed activity.
创建时间：
2016-05-17
