Crystal structure of PDE4D2 in complex with inhibitor LEO39652
收藏Protein Data Bank Japan2024-01-24 更新2026-03-21 收录
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Crystal structure of PDE4D2 in complex with inhibitor LEO39652 Descriptor: 1,2-ETHANEDIOL, 2-methylpropyl 1-[8-methoxy-5-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate, DIMETHYL SULFOXIDE, ... Authors: Akutsu, M, Hakansson, M, Welin, M, Svensson, A, Logan, D.T, Sorensen, M.D. Deposit date: 2020-06-08 Release date: 2020-09-23 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3 H -isobenzofuran-5-yl)-[1,2,4]triazolo[1,5- a ]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel "Dual-Soft" PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis. J.Med.Chem., 63, 2020
创建时间：
2020-06-08
