Standardized whole-blood transcriptional profiling enables the deconvolution of complex induced immune responses. Homo sapiens

The study employs a standardized whole-blood stimulation systems to test the hypothesis that responses to Toll-like receptor ligands or whole microbes can be defined by the combined transcriptional signatures of key effector cytokines. Overall design: The study encompasses the analysis of 21 distinct whole blood stimulations from 25 healthy donors from the Milieu Interieur Cohort (www.clinicaltrials.gov identifier: NCT01699893)