Genome-wide CUT&RUN sequencing of H3K27me3 mark across different stages of T-cell development.

We present CUT&RUN sequencing of H3K27me3 for hematopoietic progenitor cells at the following differentiation stages: 1) cKit+ hematopoietic progenitor cells from bone marrow, 2) monoallelic Bcl11b expressing DN2 progenitors, which have one active and one inactive Bcl11b allele and 3) biallelic Bcl11b expressing DN2 progenitors, which have both Bcl11b alleles active Examination of H3K27me3 in hematopoietic progenitors that have no Bcl11b expression, monoallelic Bcl11b expression, and biallelic Bcl11b expression