Metagenomic detection of central nervous system infections missed by conventional testing

Community-acquired infectious meningoencephalitis is associated withhigh rates of mortality and morbidity. Diagnostic work-up and treatment strategies arechallenging due to limited access to diagnostic tests and worldwide heterogeneity inboth clinical presentation and distribution of microorganisms. Suspected acute centralnervous system (CNS) infections were evaluated in patients with meningoencephalitisenrolled in a hospital-based surveillance study conducted in Sao Paulo, Brazil, fromMarch 2018 to November 2019.