Nck binds to the active PDGF receptor

Nck is a widely expressed protein consisting exclusively of SH2 and SH3 domains. With its SH2 doamin Nck interacts with Tyr571 of the PDGF beta-receptor and it also interacts with the alpha-receptor, but the sites of interaction have not been determined. Nck is involved in the activation of the JNK serine/threonine kinase through interaction with the serine/threonine kinases PAK1 and NIK.

Nck是一种在细胞中广泛表达的蛋白质，其由SH2和SH3结构域组成。通过其SH2结构域，Nck与PDGF-β受体上的Tyr571残基相互作用，并同样与α受体发生相互作用，然而具体的结合位点尚未得到确定。Nck通过与其中的丝氨酸/苏氨酸激酶PAK1和NIK相互作用，参与JNK丝氨酸/苏氨酸激酶的激活过程。