Characteristics of study animals.

Abbreviations: F, female; IP, incubation period; M, male; n.a., not applicable; n.d., not determined; neg., negative test result; y, years.
+, positive; (+), weakly positive; +/−, indeterminate results; +C→L, PrPres accumulations in all spinal cord segments (cervical to lumbar); C, cervical spinal cord segments; L, lumbar spinal cord segments.
1All parts of the brain including hypophysis and medulla oblongata.
2T2D pathogenesis was published elsewhere [32].
* B2, B6, C4, C5, and C6 had to be euthanized for humane reasons due to severe T2D before the prion disease onset.