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2.05 A resolution structure of MERS 3CL protease in complex with inhibitor 6b

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Protein Data Bank Japan2024-10-16 更新2026-03-21 收录
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2.05 A resolution structure of MERS 3CL protease in complex with inhibitor 6b Descriptor: N~2~-{[(trans-4-ethylcyclohexyl)oxy]carbonyl}-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide, Orf1a protein Authors: Lovell, S, Battaile, K.P, Kashipathy, M.M, Rathnayake, A.D, Zheng, J, Kim, Y, Nguyen, H.N, Chang, K.O, Groutas, W.C. Deposit date: 2020-01-09 Release date: 2020-08-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.05 Å) Cite: 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice. Sci Transl Med, 12, 2020
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2020-01-09
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