JCM data.xlsx

Design: Retrospective study at the Clinic for Oncology and Radiotherapy, University Clinical Center Tuzla.Ethics: Approved by the institutional Ethics Committee (Approval No. 02-09/2-116-3/25).Period: January 1–December 31, 2023.Population: Patients with newly diagnosed breast cancer, presented for initial multidisciplinary team (MDT) management planning.Inclusion criteria: Newly diagnosed breast cancer, no prior treatment, first presentation to MDT.Exclusion criteria: Previous malignancy or prior breast cancer treatment before MDT evaluation.Data collected: Demographics (sex, age, menopausal status), tumor characteristics (ER, PR, HER2, grade, Ki-67), and MDT treatment recommendations.Intervention: ChatGPT-4.0 queried with anonymized patient data to generate independent treatment recommendations.Example prompt: Provided patient’s age, sex, tumor type, clinical stage, receptor status, Ki-67, and grade.Blinding: Each ChatGPT query performed in a fresh session; oncologists blinded to each other’s ratings.Evaluation: Four board-certified oncologists (two MDT members, two external) independently rated ChatGPT vs. MDT recommendations using a 4-point Likert scale (1=Strongly disagree, 4=Strongly agree).Analysis: Agreement between ChatGPT and MDT, and inter-oncologist agreement, calculated; correlations with individual clinicopathological parameters assessed.