Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents
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https://figshare.com/articles/dataset/Selenoacyclovir_and_Selenoganciclovir_Discovery_of_a_New_Template_for_Antiviral_Agents/2109196
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资源简介：
On
the basis of the potent antiviral activity of acyclovir and
ganciclovir, selenoacyclovir (2a) and selenoganciclovir
(2b) were designed based on bioisoteric rationale and
synthesized via the diselenide 7 as the key intermediate.
Compound 2a exhibited potent anti-HSV-1 and -2 activities
while 2b exerted moderate anti-HCMV activity, indicating
that these nucleosides can serve as a novel template for the development
of new antiviral agents.
创建时间：
2016-02-12
