Single nuclei RNA sequencing shows the engagement of PPARD target genes primarily in hepatocytes and cholangiocytes by the selective PPAR-delta agonist seladelpar

The selective Peroxisome proliferator-activated receptor delta (PPARD) agonist seladelpar reduces liver injury and modulates bile acid metabolism in preclinical models. This study aimed to investigate the effect of seladelpar on single liver cells. The selective PPARD agonist seladelpar induced PPARD responsive genes primarily in hepatocytes and cholangiocytes. We found that seladelpar upregulated Abcb4 in hepatocytes, which might contribute to its beneficial effects in cholestatic liver disorders.