The use of tissue microRNAs to distinguish indolent and aggressive forms of prostate cancer

The low sensitivity or specificity of current parameters for prostate cancer detection leads to overdiagnosis and overtreatment of the disease. MicroRNAs are small non-coding RNAs whose level can reflect clinical and biological characteristics of the tumor. In the study, our objective was to identify miRNAs associated with disease aggressiveness, which can supplement risk stratification systems. A global miRNA profiling was performed on FFPE samples from indolent and aggressive prostate cancer. Within two-level validation, the prognostic potential of miRNAs associated with disease aggressiveness was evaluated.