Chronic Renal Insufficiency Cohort (CRIC) - GWAS

The Chronic Renal Insufficiency Cohort (CRIC study) was established in 2001 by the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) to improve the understanding of the relationship between chronic kidney disease and cardiovascular disease. The goals of the CRIC Study are to examine risk factors for progression of chronic kidney disease and cardiovascular disease among patients with chronic kidney disease and to develop predictive models to identify high-risk subgroups, informing future treatment trials and increasing application of available preventive therapies. Data available at dbGaP include genotype data for 3527 participants released in version 1. Plasma metabolomics and plasma proteomics data will be available at dbGaP in "Chronic Renal Insufficiency Cohort (CRIC) Study Metabolomics and Proteomics". Additional phenotypic, clinical, and outcomes data are available at the NIDDK Central Repository and can be linked to data available at dbGaP. More than 330 manuscripts have been published, reporting on the effects of a broad range of risk factors (from molecular biomarkers of disease pathways to clinical, demographic, and behavioral characteristics) on the progression of CKD and other health consequences. The full CRIC bibliography can be found at http://cristudy.org/Chronic-Kidney-Disease/Chronic-Renal-Insufficiency-Cohort-Study/bibliography-2024-2023. ]]>
Medications Included in the Medication Indicator Variable called: ace_inhMedications Included in the Medication Indicator Variable called: ACEARBMedications Included in the Medication Indicator Variable called: Active_VitDAFIB - Atrial Fibrillation (Yes/Not Yes)AGEAGE_INTEGERALCOH_USE - Alcohol UseMedications Included in the Medication Indicator Variable called: AllopurinolMedications Included in the Medication Indicator Variable called: alpha_gluco_inhMedications Included in the Medication Indicator Variable called: alpha2agMedications Included in the Medication Indicator Variable called: AlphablkAMPUTATION INFORMATION (AMPUT)Medications Included in the Medication Indicator Variable called: angioblkMedications Included in the Medication Indicator Variable called: ANTI_ACIDOSISMedications Included in the Medication Indicator Variable called: antidepressantMedications Included in the Medication Indicator Variable called: AntidiabetesMedications Included in the Medication Indicator Variable called: AntiepilepticsMedications Included in the Medication Indicator Variable called: AntiplateletMedications Included in the Medication Indicator Variable called: anxiolyticsANYCVD - Cardio-Vascular DiseaseArthritis - History of Rheumatoid ArthritisMedications Included in the Medication Indicator Variable called: aspirinPARTICIPANT ASSIGNMENT (ASSIGN)Asthma - History of Asthma or Reactive Airway DiseaseBECK DEPRESSION INVENTORY (BDI)Becks_Score - Becks Depression Score (Continuous)Medications Included in the Medication Indicator Variable called: BetablkMedications Included in the Medication Indicator Variable called: BiguanideMedications Included in the Medication Indicator Variable called: BILESEQUESTRANTSMedications Included in the Medication Indicator Variable called: BisphosphonatesBLACK - Black Race (Y/N) (Binary)BMI - Body Mass Index (kg/m^2)Medications Included in the Medication Indicator Variable called: BONERIBLOOD PRESSURE FORM (BP)BSA - Body SURFACE AREA (m^2)Medications Included in the Medication Indicator Variable called: CablkMedications Included in the Medication Indicator Variable called: calc_phosbinders1Medications Included in the Medication Indicator Variable called: CalciferolsMedications Included in the Medication Indicator Variable called: calciferols_extCCID - CRIC Clinic CenterCHF - Congestive Heart Failure (Yes/Not Yes)CMEDLOG MEDICATIONS - Binary Medication Indicators from the CMEDLOGCONCOMITANT MEDICATIONS (CMED)COPD - History of Chronic Obstructive Pulmonary Disease (emphysema)Medications Included in the Medication Indicator Variable called: coronaryDEMOGRAPHIC INFORMATION (DEMO)DIABETES_AT_BASELINE - Diabetes at baselineDIASTOLIC - Diastolic Blood Pressure (mmHg)Medications Included in the Medication Indicator Variable called: DigoxinMedications Included in the Medication Indicator Variable called: DiureticMedications Included in the Medication Indicator Variable called: DPP4EDU_CAT_1 - Highest level of education completedeGFR_ROCHE - ESTIMATED GLOMERULAR FILATRATION RATE (ml/min/1.73m2)ELIGIBILITY ASSESSMENT (ELIG)Medications Included in the Medication Indicator Variable called: ErythroStimFAMILYCAD - Family History of CAD (Yes/Not Yes)FAMILYRD - Family History of Renal Disease (Yes/Not Yes)FASTING - FASTINGGLOMERULAR FILTRATION RATE (GFR)HEIGHT (cm)Medications Included in the Medication Indicator Variable called: HeparinHISPANIC - Self defined Hispanic ethnicityINCOME_CAT_1 - Total Annual Household Income CategoryMedications Included in the Medication Indicator Variable called: InsulinMedications Included in the Medication Indicator Variable called: Kspare_diureticLAB_DATA - TESTS TESTS FROM THE LAB_DATALABCBC VariablesLABORATORY RESULTS (LABCBC)LEFTABI - Left Ankle Brachial IndexMedications Included in the Medication Indicator Variable called: LipidLIPID_DATA VARIABLES - Variables from Lipid CRFMedications Included in the Medication Indicator Variable called: Loop_diureticLOWABI - Lower of Right or Left ABIMAP - Mean Arterial Pressure (mmHg)MARSTAT2 - Marital Status 2MEDICAL HISTORY (MEDHX)Medications Included in the Medication Indicator Variable called: meglitinideMIREVASC - Myocardial Infarction, Prior Revascularization (Yes/Not Yes)MMSE_SCORE - MODIFIED MINI-MENTAL SCOREMODIFIED MINI-MENTAL STATE EXAM (MMSE)NPBCLASS - Sum of select CMEDLOG hypertension medications capped at 4NBPDRUGS - Sum of select hypertension CMEDLOG medicationsMedications Included in the Medication Indicator Variable called: non_calc_phosbindersMedications Included in the Medication Indicator Variable called: non_sel_sriMedications Included in the Medication Indicator Variable called: NSAIDMedications Included in the Medication Indicator Variable called: other_lipidPHYSICAL ASSESSMENT (PHYSASSESS)PIDMedications Included in the Medication Indicator Variable called: prednisonePULSE - PULSE (beats/minute)PVD - Peripheral Vascular Disease (Yes/Not Yes)RACE_CAT_1 - Race Category 1Race_Ethnicity_Cat2 - Race-Ethnicity Category (4 level)RIGHTABI - Right Ankle Brachial IndexsCR_ROCHE - Roche Adjusted Serum Creatinine (mg/dL)SCREENING LABORATORY RESULTS (SCRLAB)Medications Included in the Medication Indicator Variable called: SERMsSEXSMOKE100 - Smoked 100 cigarettes in lifetimeSMOKENOW - Current SmokerSPECIMEN COLLECTION (SPECIMEN)Medications Included in the Medication Indicator Variable called: ssriMedications Included in the Medication Indicator Variable called: StatinsMedications Included in the Medication Indicator Variable called: SteroidsSTROKE - Stroke (Yes/Not Yes)Medications Included in the Medication Indicator Variable called: SulfonylureaSYSTOLIC - Systolic Blood Pressure (mmHg)Medications Included in the Medication Indicator Variable called: Thiaz_diureticMedications Included in the Medication Indicator Variable called: TZDUALBUMIN24H - Urine Albumin collected in 24 hours (g/24H)UCOLTIME - URINE COLLECTION TIMEUCREATININE24H - Urine CREATININE collected in 24 hours (g/24H)UPROTEIN24H - Urine protein collected in 24 hours (g/24H)URINE_PROTEIN_MG_DL - Urine Protein mg/dLURINE_TOTAL_VOLUME - Urine Total VolumeMedications Included in the Medication Indicator Variable called: vasodilWAIST - Waist Circumference (cm)WEIGHT (kg)WHITE - White Race (Binary)Linking CRIC Study SUBJECT ID in dbGaP with other data sourcesPhenotype data cat variable definitions formatParticipants are no longer being enrolled in the study. The following Inclusion/Exclusion Criteria were followed at the time of participant recruitment. Inclusion for participants enrolled in phase 1: 21 to 74 years; Age Based eGFR: 21-44 years 20-70 ml/min/1/73m2), 45-64 years 20-60 ml/min/1/73m2, 65-74 years 20-50 ml/min/1/73m2.Inclusion for participant enrolled in phase 3: 45 to 79 years; eGFR 45-70 ml/min; Primarily proteinuric CKD Exclusion: Institutionalized, unable or unwilling to provide informed consent, participant appears unlikely or unable to participate in the required study procedures as assessed by the investigator, study coordinator or designee, NYHA Class III or IV heart failure at baseline, known cirrhosis based on patient self-report, known ADPKD, known HIV infection and/or AIDS based on patient self-report, present participation in the AASK Cohort Study, pregnant women.]]>
2001: design of the study began 2004-2008: recruitment of participants conducted resulting in over 3000 enrolled participants2008: phase 2 of the study began, follow-up of cohort2013: Phase 3 of the study began, new recruitment and continued follow-up of the existing cohort2013- 2015: Recruitment of Phase 3 cohort (n=1560 additional participants)2018: Phase 4 of the study began, continued follow-up of the cohort2023: Phase 5 of the study began, participant follow-up extended for 3 additional years]]>