Diet-Induced Obesity Leads to Infarct Expansion, increased neuroinflammation, and Worsened Outcomes after Stroke

We used RNA-seq to show that high-fat-diet-fed mice have a larger neuroinflammatory response following stroke. Elucidating these mechanisms may lead to the development of treatments that will benefit people with obesity who suffer from a stroke. Overall design: 145 C57BL/6J mice were either fed a 60% kCal fat diet or 6% kCal fat diet for 6 or 15 weeks. Focal ischemia was induced and brain tissue was harvested for RNA-seq.