Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: <i>Swertia mileensis</i>
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资源简介：
Swerilactones C (1) and D (2), two novel diastereomeric lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb Swertia mileensis. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic methods and further confirmed by X-ray single-crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited inhibitory activities against the secretion of HBsAg (IC50 = 1.24 and 2.96 mM, respectively) and HBeAg (IC50 = 0.77 and 1.47 mM, respectively).
创建时间：
2016-02-25
