BDNF activates NTRK2 (TRKB) signaling

Signaling by the neurotrophin receptor tyrosine kinase NTRK2 (TRKB) can be activated by binding to brain-derived neurotrophic factor (BDNF), which functions as a ligand for NTRK2 (Soppet et al. 1991, Klein et al. 1991). Binding to BDNF triggers NTRK2 dimerization (Ohira et al. 2001) and trans-autophosphorylation of NTRK2 dimers on conserved tyrosine residues in the cytoplasmic tail of the receptor (Guiton et al. 1994, Minichiello et al. 1998, McCarty and Feinstein 1999). Phosphorylated tyrosine residues subsequently serve as docking sites for recruitment of effector proteins that trigger downstream signaling cascades.

神经生长因子受体酪氨酸激酶NTRK2（TRKB）的信号传导可通过与脑源性神经营养因子（BDNF）的结合而激活，BDNF充当NTRK2的配体（Soppet等，1991年，Klein等，1991年）。BDNF的结合可引发NTRK2的二聚化（Ohira等，2001年）以及NTRK2二聚体在受体胞浆尾部的保守酪氨酸残基上的跨自磷酸化（Guiton等，1994年，Minichiello等，1998年，McCarty和Feinstein，1999年）。随后，磷酸化的酪氨酸残基作为效应蛋白招募的锚定位点，触发下游信号级联反应。