Overview of FGF-ligand and FGF-receptor expression during CNS development.

Quantitative RT-PCR expression levels were classified based on ΔCT values to Gapdh reference gene into: high (ΔCTT 6–11), low (ΔCT>11–15) or not detected (n.d., ΔCT>15). The qRT-PCR data is summarized across all tissues VM, STR and SC and all developmental stages analyzed, for detailed expression profiles see indicated figures. Available ISH datasets of the ALLEN brain atlas were analyzed for up to 8 stages (E11.5, E13.5, E15.5, E18.5, P4, P14, P28, P56) for SC, VM and STR. The table summarizes developmental stages with detectable expression.*Although, FgfR-1, FgfR-2 and FgfR-3 in situ probes are homologous to FgfR c spliceforms, also b splice forms might be detected. Due to high abundance of c isoforms in CNS most likely these isoforms have been detected by ISH.